The effects of vegf on deep venous thrombosis in the

The Effects Of Vegf On Deep Venous Thrombosis In The-Free PDF

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The effects of VEGF on deep venous thrombosis in the perioperative period of elderly fracture patients. factor analysis of variance was used for analyzing the showed an increase at first followed by a decrease which. measurement difference between different groups If the indicated that the operation might cause an increase in. difference was statistically significant a further LSD test serum VEGF levels The thrombosis group showed higher. preceded between the two different groups Analysis of VEGF levels compared to the non thrombosis group after. the correlation between VEGF D Dimer and fibrinogen the operation for different days differences were. content was carried out R2 represents the strength of the statistically significant P 0 05 Serum VEGF levels in. correlation whereas P 0 05 is regarded as statistically the thrombosis group increased significantly and its peak. significant levels were significantly higher than the non thrombosis. group which indicated that the formation of thrombus. RESULTS was closely related to the increase in VEGF level The. results are depicted in table 2,Comparison of general conditions. The thrombosis group included 16 cases of male and 13 Serum D Dimer content. female cases which were an average of 73 12 4 62 years Serum D Dimer content of the thrombosis and non. old with average weights of 79 48 8 76 Kg and had an thrombosis group before the operation was compared. average BMI of 25 59 2 28 The non thrombosis group difference was statistically significant P 0 05 The. comprised of 25 cases of male and 14 female cases which serum D Dimer content in the thrombosis and non. were an average of 71 65 4 14 years old weighed an thrombosis group first increased followed by a decrease. average of 75 32 7 43 Kg and had an average BMI of which indicated that the operation could cause an increase. 24 24 2 19 Comparison of the general condition showed in serum D Dimer content The thrombosis group showed. that there was an evident difference between weight and a higher serum D Dimer content compared to the non. BMI in these two groups P 0 05 It indicated that the thrombosis group after treating for different days. heavier group and higher BMI group was more likely to difference was statistically significant P 0 05 The. have DVT However there were no significant serum D Dimer content in the thrombosis group increased. differences between the gender and age of these two significantly and its peak level was significantly higher. groups P 0 05 Results are shown in table 1 than the non thrombosis group which indicated that the. formation of thrombosis was closely related to the. Serum VEGF levels increase of D Dimer content table 3. Comparison of the serum VEGF levels of the thrombosis. group and the non thrombosis group before operation The relationship between VEGF levels and D Dimer. showed statistically significant differences P 0 05 content in the thrombosis group at the time of T2 and T4. After the operation serum VEGF levels in both groups was strong and the Pearson factor was 0 681 R2 0 892. Table 1 Comparison of general conditions,Gender Average Age. Groups n Weight Kg Weight Index,Male Female year, Thrombosis 29 16 13 73 12 4 62a 79 48 8 76a 25 59 2 28a. Non thrombosis 39 25 14 71 65 4 14a 75 32 7 43a 24 24 2 19a. 2 or t value 0 5540 1 3781b 2 1151b 2 4704b,P value 0 4567 0 1728 0 0382 0 0161. Note a data is expressed as x s b is t value, Table 2 VEGF level x s pg ml in peripheral venous serum.
Group n T1 T2 T3 T4, Thrombosis 29 345 5 44 7 499 3 77 5 588 2 97 6 395 8 66 7. Non thrombosis 39 363 1 51 3 441 6 83 2 493 5 84 3 364 3 59 3. T value 1 4766 2 9112 4 2826 2 0539,P value 0 1445 0 0049 0 0001 0 0439. Table 3 D Dimer content in peripheral venous serum x s ng ml. Group N T1 T2 T3 T4, Thrombosis 29 65 5 11 2 196 3 57 5 261 2 77 4 88 5 14 7. Non thrombosis 39 63 1 10 3 159 4 44 2 198 5 61 2 69 2 12 1. T value 0 9155 2 9934 3 7307 5 9335,P value 0 3633 0 0039 0 0004 0 0000. 2800 Pak J Pharm Sci Vol 31 No 6 Special November 2018 pp 2799 2803. Huiliang Zhang et al, Table 4 Fibrinogen content in peripheral venous serum x s mg dL.
Group n T1 T2 T3 T4, Thrombosis 29 125 5 21 2 172 5 36 2 219 5 51 4 181 5 44 6. Non thrombosis 39 128 4 25 3 153 4 34 6 164 5 41 1 139 2 35 5. T value 0 5001 2 2074 4 9024 4 3545,P value 0 6186 0 0308 0 0000 0 0000. Table 5 Thrombo elastogram results comparison between before and after operation. Group Cases Thrombo elastogram low blood coagulation patients n. Before operation After operation,Thrombosis 29 7 4. Non thrombosis 39 10 16,2 value 0 0200 5 9412,P value 0 8874 0 0148. P 0 05 For the non thrombosis group this relationship manifestations include unilateral or bilateral lower limb. was weak and the Pearson factor was 0 451 R2 0 634 swelling post thrombotic syndrome and lethal pulmonary. P 0 05 embolism which can severely affect a patient s health It. has been reported that the incidence of deep venous. Fibrinogen content in peripheral venous serum, thrombosis is approximately 1 2 worldwide Hoaglund.
The comparison of fibrinogen content between the,2004 Leung et al 2006 With regard to China. thrombosis and non thrombosis group showed that the. despite the sparsity of multicenter epidemiology, difference was not statistically significant P 0 05. investigation data available for deep venous thrombosis it. Fibrinogen content in both groups showed an increase. still be discerned that its incidence is high according to. first followed by a decrease post operation which, the analysis of literature and clinical data Ko et al 2003. indicated that operation can cause an increase in serum. Leung et al 2006 Deep venous thrombosis refers to the. fibrinogen content Comparison was done for the, abnormal coagulation of blood in the lower limbs deep. fibrinogen content between two groups post operation for. venous system which will block the venous duct and. different days The thrombosis group had higher rates. cause acute obstruction of lower limbs venous backflow. than the non thrombosis group difference was, and increase of internal pressure it will also damage the.
statistically significant The thrombosis group, venous valve and cause a series of symptoms and signs. experienced a more significant increase of fibrinogen. Sillesen et al 2005 Malone Agutter 2016 German, content and the peak level of fibrinogen content was. physiologist Virchow pointed that the main causes of. significantly higher than the non thrombosis group which. deep venous thrombosis are slow venous blood flow, indicated that the formation of thrombosis was closely. hypercoagulable state and venous wall damage the first. related to the increase of fibrinogen content table 4. two are the main reasons Any disease which can cause. The relationship between VEGF levels and fibrinogen the three problems mentioned above will be the risk. content in the thrombosis group at the time of T2 and T4 factors for deep venous thrombosis Cervantes Rojas. was strong and the Pearson factor was 0 742 R2 0 921 2005 VEGF is a specific vascular permeability factor and. P 0 05 For the non thrombosis group this relationship chemotactic factor of vascular endothelial cells Trelinski. was weak and the Pearson factor was 0 429 R2 0 611 et al 2010 During the embryonic growth and. P 0 05 development stage the formation of the embryonic. vascular system is dependent on the correct expression of. The thrombo elastogram results comparison before and VEGF After birth VEGF still plays an important role in. after operation the formation of blood vessels Endothelial progenitor. Before the operation 7 cases in thrombosis group cells can migrate to peripheral blood when signaled by. 24 14 and 10 cases in non thrombosis group exogenous VEGF VEGF can improve the proliferation. 25 64 showed low blood coagulation the difference migration and chemokines of endothelial progenitor cells. was not statistically significant P 0 05 After the which can also promote angiogenesis It has been reported. operation 4 cases in thrombosis group 13 79 and 16 that the number of endothelial progenitor cells in the. cases in non thrombosis group 41 03 experienced a recycling of peripheral blood increased significantly in a. reduction of blood coagulability difference was VEGF rich microenvironment Also a hypoxic. statistically significant P 0 05 Results are shown in microenvironment can further improve the proliferation. table 5 and differentiation of endothelial progenitor cells and. DISCUSSION finally enhance the effects of endothelial progenitor cells. on improving angiogenesis After the formation of, Deep venous thrombosis is a very common complication. thrombosis due to the blood flow stasis and hypoxic. of orthopedic patients on bed rest Its clinical, Pak J Pharm Sci Vol 31 No 6 Special November 2018 pp 2799 2803 2801.
The effects of VEGF on deep venous thrombosis in the perioperative period of elderly fracture patients. microenvironment VEGF and BFGF content inside of the stimulate the expression of VEGF in order to improve. emboli increase significantly Therefore the thrombolysis neovascularization and to repair the trauma In the. and organization speed increases Cacciola et al 2002 meantime the formation of deep venous thrombosis can. The possible antithrombotic mechanism of VEGF is as further increase the expression of VEGF in order to aid. follows i act as an endogenous regulator of body parts the thrombolysis process. not only in the participation of the maintenance of the. integrity of vascular endothelial cells but also to maintain CONCLUSION. the normal physiological functions to prevent the, occurrence of endogenous and exogenous coagulation ii VEGF levels had a certain relationship with D Dimer and. VEGF can increase the production of NO and PGI Wei et fibrinogen content in the formation of deep venous. al 2007 NO can activate soluble guanylate cyclase thrombosis of elderly fracture patients This relationship. SGC to increase cGMP content inside of the cell which indicated the changing of blood coagulation state and the. can finally cause platelet aggregation and block property fibrinolysis process in the formation of deep venous. decrease iii VEGF can also promote the expression and thrombosis The up regulated expression of VEGF to. activity of serine protease fibrinoclase urokinase and some extent will guide the treatment process and. tissue plasminogen These enzymes can cause the prognosis of the deep venous thrombosis Moreover. conversion of plasminogen to plasmin which will finally thrombo elastogram can fully reflect the shear stress. improve the thrombolysis Chun et al 2001 It has been changing with time in the dynamic clotting process and. reported that D Dimer fibrinogen and inflammatory precisely describe the clotting mechanism. cellular factors in the peripheral blood are closely related. to the formation of deep venous thrombosis Wuillemin et REFERENCES. al 2005 After the activation of the fibrinolytic system. of the body fibrinogen will convert to fibrin monomers Aguilar FC Martinez BA Martinez SA Del RMC Villar. which will crosslink with the factor XIII D Dimer is the SV Vazquez SM and Rodriguez RF 2002 Diagnostic. product of the fibrinolytic enzyme hydrolysis process value of D dimer in patients with a low pretest. The accumulation of fibrinogen in plasma can enhance probability of deep venous thrombosis of lower. fibrinolytic activity and also increase D Dimer content extremities Med Clin Barc 118 539 542. Therefore D Dimer can specifically induce the Bates SM Jaeschke R Stevens SM Goodacre S Wells. hypercoagulable state of blood and hyper function of the PS Stevenson MD Kearon C Schunemann HJ. fibrinolysis process at the molecular level Chan et al Crowther M Pauker SG Makdissi R and Guyatt GH. 2010 Aguilar et al 2002 D Dimer index can increase 2012 Diagnosis of DVT Antithrombotic therapy and. several times during the formation of deep venous prevention of thrombosis 9th ed American college of. thrombosis Bates et al 2012 Schutgens et al 2003 chest physicians Evidence Based clinical practice. The clinical way to detect D Dimer and fibrinogen is easy guidelines Chest 141 e351S e418S. and efficient which is of great significance in the Bozoglu E Dinc A Erdem H Pay S Simsek I and Kocar. diagnosis of deep venous thrombosis and evaluation of IH 2005 Vascular endothelial growth factor and. the prognosis monocyte chemoattractant protein 1 in Behcet s. patients with venous thrombosis Clin Exp Rheum, Our study has found that VEGF levels in both these two 23 S42 S48. groups showed an increase at first and followed by a Brummel Ziedins KE Vossen CY Butenas S Mann KG. decrease which indicated that the angiogenesis process and Rosendaal FR 2005 Thrombin generation. after operative injury can cause an increase of serum profiles in deep venous thrombosis J Thromb. VEGF levels The thrombosis group showed higher Haemost 3 2497 2505. VEGF levels compared to the non thrombosis group after Cacciola RR Di Francesco E Giustolisi R and Cacciola E. the operation for different days difference was 2002 Elevated serum vascular endothelial growth. statistically significant Serum VEGF levels in the factor levels in patients with polycythemia vera and. thrombosis group increased significantly and its peak thrombotic complications Haematol 87 774 775. level was significantly higher than the non thrombosis Cervantes J and Rojas G 2005 Virchow s Legacy Deep. The effects of VEGF on deep venous thrombosis in the perioperative period of elderly fracture patients Yingliang fibrinogen and thrombo elastogram was done 68 elderly fractured patients that had undergone surgery were divided into two groups according to whether they were diagnosed with deep venous thrombosis in the perioperative period or not ELISA assays was carried out to detect the

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