Glyconutritionals Consolidated Review of Potential Benefits

Glyconutritionals Consolidated Review Of Potential Benefits-Free PDF

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ars were constructed from dietary glucose This theory stood Substantially reduce pain and increase joint mobility in. for many years without testing Recently however new osteoarthritis patients 44 45 46 47 48. technology has enabled testing of the glucose only theory. It proved false We now know that the body not only Cancer. absorbs these various sugars intact from the gastrointestinal Glyconutrients help to inhibit growth and or tumor cell. tract but in many cases actually prefers to obtain them metastasis in certain types of cancer 12 49 50 51 52 53 54 55 56 57 58. from diet Obtaining these sugars from dietary sources is 59 60 61 62 63. more efficient than obtaining them through multi step. enzymatic conversions from glucose because less energy and Microbial Infections. less time are required Glyconutrients help kill bacteria viruses and fungi and. Below is a list of health related benefits that have been thereby defend against infections 62 64 65 66 67 68 69 70 71. associated with single sugars combinations of sugars or For example they were shown to inhibit eye infection 72. sugar containing glycoconjugates This list includes infor They help protect against lung infections and injury by. mation obtained from in vitro test tube studies animal inactivating inhaled bacteria and viruses trapped in air. studies single human case reports and large human clinical way mucus 114 115. trials In the human studies various routes of administra. tion and various dosage amounts were used None of these Diabetes and Metabolic Disorders. studies reach the standard of proof required for drugs On Glyconutrients. the other hand nutritional supplement products are highly Are an effective treatment for certain diseases caused by. safe compared to drugs This is because they support nor inborn errors of metabolism 73. mal healthy structure and function and are not intended to Are an effective treatment for Carbohydrate Deficient. alter or override normal physiology Glycoprotein Syndrome CDGS 74 75 76. Following the list of Consolidated Benefits is a list of Are important in regulating blood glucose levels and. Expanded Benefits and Mechanisms of Action that insulin release 77 78 79 80 81. includes more detailed information about how the sugars Help protect animals with diabetes and renal failure. work in the body Please refer to specific footnoted refer from cataract formation in the eye 82 83 84. ences for clarification and perspective May help in treating diabetes 85 86. Nutritional supplements support normal healthy struc. ture and function of the body Individuals who are sick and Hormonal Function. who wish to use nutritional supplements to complement Glyconutrients or their metabolic products play a. standard proven therapy should discuss this with their key role in the healthy function of hormones and 87 88 89 90 91. health care professional 92 93 94 95 96 97, The majority of the results reported below were not Are important for the release and proper transport of. obtained with the use of any particular marketed glyconu hormones throughout the body 98 99 100 101 102 103. trient product This list from the scientific literature of Are required for normal function binding and. potential benefits from use of glyconutrients is intended to processing of growth hormone 104 105. point medical researchers toward areas that glyconutrients. have shown promise for improved health This information Stress. is also provided to educate consumers who may wish to Glyconutrients or their metabolic products are impor. investigate the use of glyconutrients as a safe nutritional tant during periods of body stress21 22 23 24 25 26 27 28 29 because they. complement to traditional therapy can,Remove environmental chemicals from cells before. CONSOLIDATED BENEFITS they have a chance to exert toxic effects 106 107 108 109 110. 111 112 113, Immune System Modulation Help protect against lung infections and injury follow. Glyconutrients or their metabolic products are neces ing stress by inactivating inhaled bacteria and viruses. sary for healthy immune cells and immune system trapped in airway mucus 114 115. function 4 5 6 7 8 9 10 They have been shown to Assist the body in developing tolerance to heat by. Play key roles in many aspects of tissue healing and contributing to the protection and damage repair of. repair as well as cell survival 11 12 13 14 15 16 17 18 19 20 21 22 23 24 cells during heat stress 29 116 117 118 119 120 121 122 123. 25 26 27 28 29 Help protect against opportunistic infections stomach. Enhance immune system function 30 ulcers and altered behavior caused by psychological. Have positive effects on asthma 31 32 33 stress 124 125 126 127 128 129 130 131 132 133 134 135 136 137. Have positive effects on rheumatoid arthritis 34 Help protect and repair stressed cells during intense. Have positive effects on lupus erythematosis 35 exercise 138 139. Improve the symptoms of periodontal disease canker Help mediate tissue injury repair following physical. sores and fever blisters 36 37 38 39 stress conditions such as tissue abrasion and. Suppress the skin reaction of allergic contact burns 140 141 142 143 144 145 146. dermatitis 40 Help protect against oxidative stress 147 148 149. Inhibit bronchial allergic reaction 41,Prevent arthritis 42 43. GlycoScience Vol 2 No 15 July 6 2001 2, Other Biological Effects be readily absorbed3 199 200 201 202 203 204 205 206 207 and directly.
Glyconutrients incorporated glycosylated into glycoconjugates 2 204. Stimulate calcium absorption which could be beneficial The body prefers to utilize glyconutritional sugars. in preventing calcium deficiency diseases such as provided in the diet which requires less expenditure of. osteoporosis 150 energy and allows for more rapid production of needed. Aid in protection and normal function of the gastroin glycoconjugates 2 73 204. testinal tract 151 152 Glyconutritional sugars on the surface of one cell bind. Help maintain normal colonic bacteria which is to sugar receptors on another cell which allows the. necessary for healthy digestion 153 cells to communicate with one another to develop. May increase memory in Alzheimer s patients 154 nerves muscles bones and organs and defend against. May reduce craving in smokers155 and alcoholics 156 bacterial infections and allergies 64 65. Aid in healthy processing of cholesterol 157 158 159 Glycoconjugates and glyconutritional sugars are. Help regulate proper nerve function 160 161 162 anchored to the surface of cells by glycosylphos. May help relieve symptoms of chronic fatigue phatidylinositols which are molecules found in abun. syndrome and fibromyalgia 163 164 165 166 dance in human breast milk and are of particular. May help lessen the severity of attention deficit hyper importance to the health of newborn infants 176 177. activity disorder ADHD 167 168 169, May improve growth and function of children with Immune System Modulation. Tay Sachs disease 170 Healthy immune system function depends on proper. May help with conventional drug therapy in the glycosylation of immunoglobulin proteins 4 5 6 7 8 9 and. treatment of muscular dystrophy 171 immune cells 10. May help improve growth in toddlers with failure to Immunoglobulin A in human breast milk which. thrive syndrome 172 173 contains sialic acid NANA fucose galactose N acetyl. May improve the symptoms of dyslexia 174 glucosamine and N acetylgalactosamine binds to aller. May improve serum liver enzyme levels in individuals genic substances to which the mother has been exposed. with hepatitis C 175 and prevents them from causing an allergic response in. nursing infants 177, Glyconutrients In Human Breast Milk Glyconutritional sugars on the surface of blood vessel. Glyconutrients sialic acid NANA fucose galactose N lining cells and immune cells are important cell cell. acetylglucosamine and N acetylgalactosamine are of par communication signals that direct immune cells where. ticular importance to the health of newborn infants and are to leave the blood stream to access damaged or infected. found in abundance in human breast milk 176 177 tissue so they can destroy and clear away infectious. Glyconutrients in breast milk play a key role in the follow microorganisms 10 71 208. ing benefits for nursing infants Mannose galactose and polysaccharides containing. Inhibition of respiratory viruses and killing of these sugars facilitate wound healing11 12 13 by activating. bacteria 177 178 179 180 macrophages which are immune system cells that. Prevention of diarrhea caused by microbial orchestrate the release of various bioactive substances. infections 181 182 that modulate the immune response and tissue. Prevention of allergies 177 inflammation 14 15 16 17 and also digest bacteria and. Proper iron absorption 183 cellular debris 11 18 19 20. Bioavailability of vitamin B12 184 When macrophages digest dead blood cells and cellular. Normal healthy development and function of the fat debris at a site of inflammation they recognize which. digestion system 185 186 187 188 189 190 191 192 cells are dead by the glyconutritional sugars expressed. Normal healthy brain development 177 193 194 195 on their cell surface 209. Glyconutritional sugars on a blood protein block the. EXPANDED BENEFITS AND MECHANISMS OF ACTION attachment of lymphocytes type of blood cell to blood. vessel lining cells which is necessary for tissue inflam. Following is a list of expanded benefits and mechanisms mation to occur 210 211. of action that includes more detailed information about Glyconutritional sugars were shown to enhance. how the sugars work in the body immune function in an animal study 30. Glyconutritional sugars have positive health implica. Overview tions in asthma and rheumatoid arthritis immune. Body proteins and fats bind to glyconutrients sugars to system inflammatory diseases since pro inflammatory. form glycoconjugates glycoproteins glycolipids cells and molecules are suppressed by mannose or. which function as enzymes immune system molecules N acetylglucosamine 31 32 33 34. hormones and cell membrane transport molecules and Fucose suppresses the skin reaction of allergic contact. are involved in all aspects of human health structure dermatitis 40 and sialic acid NANA inhibits bronchial. and function 196 197 198 allergic reaction41 in animals. Glyconutritional sugars which include mannose An arthritic response in animals can be prevented by. galactose fucose xylose glucose sialic acid NANA giving polymers of mannose either orally or by. N acetyl glucosamine and N acetylgalactosamine can injection into an arthritic joint 42 43. GlycoScience Vol 2 No 15 July 6 2001 3, Glucosamine a metabolic product of N acetylglu promoting the growth of beneficial bifidobacteria in the. cosamine substantially reduces pain and increases joint intestines 181 182. mobility in osteoarthritis patients 44 45 46 47 48 Antiviral activity of glyconutritional sugars appears to. Patients with rheumatoid arthritis have immunoglobu be due to their ability to stimulate macrophages. lin that lacks galactose which appears to be a factor immune cells to release interferon which is toxic to. contributing to the disease since the extent of missing viruses 16 and to inhibit glycosylation of the protein. galactose correlates with disease severity and reverses in coating of viruses which interferes with normal viral. disease remission 212 213 function 62 71, Blood levels of fucose are reduced in patients with Mannose containing saccharides and N acetylglu. rheumatoid arthritis and the extent of reduction cosamine have been shown to inhibit eye infection. correlates with the severity of the disease 214 caused by an amoeba a type of infectious cell 72. Glyconutritional supplements had positive effects on Mannose binding on microbial surfaces may result in. patients with lupus erythematosus 35 enhanced uptake and destruction of microorganisms by. body cells 225 226, Many of the glyconutritional sugars including Diabetes and Metabolic Disorders.
fucose 49 50 51 52 53 galactose12 49 54 55 56 57 58 mannose or a Metabolic disorders that result from an inability to. mannose containing polysaccharide49 59 60 61 glucosamine properly metabolize glyconutritional sugars or synthe. metabolic product of N acetylglucosamine 59 62 and size glycosylate necessary glycoconjugates are. N acetylgalactosamine 63 inhibit growth and or tumor detectable and treatable by dietary supplementation. cell metastasis in certain cancers with selective sugars 73. Inhibition of cancer growth by glyconutritional sugars Daily oral mannose administration is a successful. such as mannose appears to be partially related to therapy for carbohydrate deficient glycoprotein. immune system activation of natural killer cells a type syndrome CDGS in which there is diminished. of white blood cell that destroys cancer cells 16 215 incorporation of mannose into glycoproteins 74 75 76. Glyconutritional sugars appear to inhibit tumor cell Common diseases or disorders that involve abnormal. metastasis by preventing the attachment of tumor cells glycosylation include liver disease 227 228 229. to normal cells by competing for glyconutritional sugar cancer 230 231 232 233 234. and hypothyroidism while some, binding sites on the cell surfaces 216 less common ones include immunoglobulin A. nephropathy 236 I cell disease Hereditary Erythroblastic. Microbial Infection Multinuclearity with Positive Acidified Serum and. Glyconutrients or their metabolic products are impor tant during periods of body stress 21 22 23 24 25 26 27 28 29 because they can Remove environmental chemicals from cells before they have a chance to exert toxic effects 106 107 108 109 110 111 112 113 Help protect against lung infections and injury follow ing stress by inactivating inhaled bacteria and viruses trapped in airway mucus

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