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AIR POLLUTION AND CANCER, EDITED BY KURT STRAIF AARON COHEN AND JONATHAN SAMET. IARC SCIENTIFIC,PUBLICATION NO 161, Published by the International Agency for Research on Cancer. 150 cours Albert Thomas 69372 Lyon Cedex 08 France. International Agency for Research on Cancer 2013, Distributed by WHO Press World Health Organization 20 Avenue Appia 1211 Geneva 27. Switzerland tel 41 22 791 3264 fax 41 22 791 4857 email bookorders who int. Publications of the World Health Organization enjoy copyright protection in accordance with the. provisions of Protocol 2 of the Universal Copyright Convention All rights reserved. The designations employed and the presentation of the material in this publication do not imply the. expression of any opinion whatsoever on the part of the Secretariat of the World Health Organization. concerning the legal status of any country territory city or area or of its authorities or concerning. the delimitation of its frontiers or boundaries, The mention of specific companies or of certain manufacturers products does not imply that they. are endorsed or recommended by the World Health Organization in preference to others of a similar. nature that are not mentioned, Errors and omissions excepted the names of proprietary products are distinguished by initial.
capital letters, The authors alone are responsible for the views expressed in this publication. The International Agency for Research on Cancer welcomes requests for permission to reproduce. or translate its publications in part or in full Requests for permission to reproduce or translate IARC. publications whether for sale or for noncommercial distribution should be addressed to the IARC. Communications Group at com iarc fr,Cover photograph Associated Press. IARC Library Cataloguing in Publication Data, Air pollution and cancer editors K Straif A Cohen J Samet. IARC Scientific Publications 161, 1 Air Pollutants 2 Environmental Pollutants 3 Air Pollution Indoor. 4 Carcinogens Environmental 5 Inhalation exposure adverse effects. I K Straif II A Cohen III J Samet IV Series, I Straif Kurt Cohen Aaron Samet Jonathan II Series.
ISBN 978 92 832 2166 1 NLM Classification W1,ISSN 0300 5085. Contributors 1,Chapter 1 Introduction 7,Jonathan M Samet. Chapter 2 Geographical distribution of air pollutants 13. Klea Katsouyanni, Chapter 3 Characterizing exposures to atmospheric carcinogens 29. Barbara Turpin,Chapter 4 Combustion emissions 37,Armistead Ted Russell. Chapter 5 Sources of air pollution gasoline and diesel engines 49. Daniel S Greenbaum,Chapter 6 Household use of biomass fuels 63.
Isabelle Romieu and Astrid Schilmann, Chapter 7 Polycyclic aromatic hydrocarbons in ambient air and cancer 75. Erik Dybing Per E Schwarze Per Nafstad Katarina Victorin and Trevor M Penning. Chapter 8 Hazardous air pollutants approaches and challenges in identifying. assessment priorities 95,John J Vandenberg,IARC SCIENTIFIC PUBLICATION 161. Chapter 9 Household air pollution 101, Nigel Bruce Imran Choudhury Mukesh Dherani Heather Adair Rohani and Dan Pope. Chapter 10 Using experimental data to evaluate the carcinogenicity of mixtures in. air pollution 111,Joe Mauderly, Chapter 11 Mechanistic considerations for air pollution and lung cancer genotoxicity and. molecular biomarker data from experimental and human studies 123. Kirsti Husgafvel Pursiainen, Chapter 12 Biomarkers of air pollution DNA and protein adducts 149.
Paolo Vineis, Chapter 13 Combined effect of air pollution with other agents 165. Jonathan M Samet,CONTRIBUTORS,Kurt Straif Tony Fletcher. International Agency for Research on Cancer Public and Environmental Health Research. Lyon France Unit,London School of Hygiene and Tropical. Aaron Cohen London United Kingdom,Health Effects Institute Daniel S Greenbaum. Boston MA USA,Health Effects Institute,Boston MA USA.
Jonathan M Samet,University of Southern California Uwe Heinrich. Los Angeles CA USA,Fraunhofer Institute of Toxicology and. Aerosol Research,Hannover Germany,Advisory Group participants 1. Kirsti Husgafvel Pursiainen,Erik Dybing Department of Industrial Hygiene and. Toxicology,Division of Environmental Medicine,Finnish Institute of Occupational Health.
Norwegian Institute of Public Health,Helsinki Finland. Oslo Norway, Most of the Advisory Group participants provided a manuscript expanding on their presentation updated their. manuscript again before final publication of the book and also contributed to the Advisory Group s recommendations. regarding the development of a series of Monographs on air pollution. IARC SCIENTIFIC PUBLICATION 161,Klea Katsouyanni Kirk R Smith. Department of Hygiene and Epidemiology Environmental Health Sciences. University of Athens Medical School University of California. Athens Greece Berkeley CA USA,Daniel Krewski Barbara Turpin. McLaughlin Centre for Population Health New Jersey Agricultural Experiment Station. Risk Assessment Rutgers University,University of Ottawa New Brunswick NJ USA.
Ottawa Canada,John J Vandenberg,Joe Mauderly,National Center for Environmental. National Environmental Respiratory Center Assessment. Lovelace Respiratory Research Institute United States Environmental Protection. Albuquerque NM USA Agency,Washington DC USA,Isabelle Romieu. Paolo Vineis,Centro de Investigaci n en Salud Poblacional. Instituto Nacional de Salud P blica Department of Epidemiology and Public. Cuernavaca Morelos Mexico Health,Imperial College St Mary s Campus. London United Kingdom,Armistead Ted Russell,School of Civil and Environmental.
Engineering Representative,Georgia Institute of Technology. Atlanta GA USA,Kyriakoula Ziegler Skylakakis, Jonathan M Samet Meeting Chair European Commission. Luxembourg,Department of Epidemiology,Johns Hopkins University. Baltimore MD USA,Air pollution and cancer,IARC Secretariat Christiana Demetriou. School of Public Health,Robert A Baan Imperial College.
Paolo Boffetta London United Kingdom,Paul Brennan,Vincent James Cogliano Head of Programme. Fatiha El Ghissassi,Mukesh Dherani, Yann Grosse Department of Public Health and Policy. B atrice Secretan University of Liverpool,Liverpool United Kingdom. Kurt Straif,Andreas Ullrich WHO Geneva,Per Nafstad. Division of Epidemiology, Other contributors 2 Norwegian Institute of Public Health.
Oslo Norway,Heather Adair Rohani,Trevor M Penning,Department of Public Health and. Environment Perelman School of Medicine, World Health Organization University of Pennsylvania. Geneva Switzerland Philadelphia PA USA,Nigel Bruce Dan Pope. Department of Public Health and Policy Department of Public Health and Policy. University of Liverpool University of Liverpool,Liverpool United Kingdom Liverpool United Kingdom. Imran Choudhury Astrid Schilmann, Brent and Harrow Primary Health Care Trust Centro de Investigaci n en Salud Poblacional.
London United Kingdom Instituto Nacional de Salud P blica. Cuernavaca Morelos Mexico, The following people updated original manuscripts before final publication of the book or are co authors of original. manuscripts but were not present at the Advisory Group meeting. IARC SCIENTIFIC PUBLICATION 161,Per E Schwarze,Department of Air Pollution and Noise. Norwegian Institute of Public Health,Oslo Norway,Katarina Victorin. Institute of Environmental Medicine,Karolinska Institute. Stockholm Sweden,Production team,Jennifer Brandt Technical Editor.
Karen M ller English Editor,Sylvia Lesage Editorial Assistant. Sol ne Quennehen Editorial Clerk,Elisabeth Elbers Publications Technician. Emissions from motor vehicles industrial focused Advisory Group to plan a series of IARC. processes power generation the household Monographs on air pollution. combustion of solid fuel and other sources pollute In December 2004 this special Advisory. the ambient air across the globe The precise Group meeting was convened in Lyon. chemical and physical features of ambient air Participants provided a state of the art overview. pollution which comprise a myriad of individual on topics related to exposure characterization. chemical constituents vary around the world atmospheric and engineering sciences epidemi. due to differences in the sources of pollution ological studies on cancer results of pertinent. climate and meteorology but the mixtures of cancer bioassays and data elucidating potential. ambient air pollution invariably contain specific mechanisms of carcinogenicity of compounds. chemicals known to be carcinogenic to humans related to air pollution These presentations were. Recent estimates suggest that the disease followed by discussions in subgroups estab. burden due to air pollution is substantial lished according to the structure of the IARC. Exposure to ambient fine particles PM2 5 was Monographs exposure cancer in humans. recently estimated to have contributed 3 2 million cancer in experimental animals and other rele. premature deaths worldwide in 2010 due largely vant data and plenary sessions to identify all. to cardiovascular disease and 223 000 deaths major issues that were critical for the develop. from lung cancer More than half of the lung ment of the series of Monographs Specifically. cancer deaths attributable to ambient PM2 5 were the participants were tasked with the following. estimated to have been in China and other East Develop a list of agents and exposures to be. Asian countries Lim et al 2012 evaluated in a series of IARC Monographs on air. In February 2003 the IARC Monographs pollution and cancer. Advisory Group on Priorities for Future, Evaluations recommended that IARC develop Identify the key issues to consider in the. a series of Monographs on air pollution The evaluations and critical research gaps. topic is obviously complex given the variety Make recommendations for bundling. of environments where exposures to airborne related agents into the same meeting. carcinogens take place the diversity of the Make recommendations on the sequencing. sources and the numerous components of the and scheduling of the meetings. air pollution mixture that may contribute to According to these recommendations subse. its carcinogenicity Recognizing this the 2003 quent Monographs meetings were held over the. Advisory Group recommended that there be a next few years. IARC SCIENTIFIC PUBLICATION 161, Volume 92 October 2005 Some non het Two of the original manuscripts by Vineis. erocyclic polycyclic aromatic hydrocarbons and et al and Katsouyanni et al have been updated. some related exposures IARC 2010a with an addendum. Volume 93 February 2006 Carbon black We acknowledge the support and encour. titanium dioxide and talc IARC 2010b agement of all the contributing authors during. Volume 95 October 2006 Household the development phase of this book We extend. use of solid fuels and high temperature frying our special thanks to all the authors for their. IARC 2010c endurance and their updates of the manu. Volume 103 October 2011 Bitumens scripts The editors would also like to acknowl. and bitumen emissions and some N and edge the critical support of Jennifer Brandt the. S heterocyclic polycyclic aromatic hydrocarbons technical editor of this book and the excellent. IARC 2013a support of IARC s publications team Sol ne. Volume 105 June 2012 Diesel and gasoline Quennehen Sylvia Lesage Karen M ller and. engine exhausts and some nitroarenes IARC Nicolas Gaudin Financial support for the. 2013b initial Advisory Group meeting was provided,by World Health Organization United States.
As preparation began for the sixth meeting Environmental Protection Agency Cooperative. in this series of Monographs on air pollution Agreement No CR 831057 This contribution is. Volume 109 Ambient air pollution the need gratefully acknowledged. to provide an overview and detailed background,information on different aspects of air pollution. and cancer took on renewed importance To that References. end it was decided to update earlier draft manu, scripts that had been prepared based on pres IARC 2010b Carbon black titanium dioxide and talc. entations at the initial Advisory Group meeting IARC Monogr Eval Carcinog Risks Hum 93 1 413. in 2004 While serving as a Visiting Scientist in PMID 21449489. IARC 2010c Household use of solid fuels and high tem. the IARC Monographs section Aaron Cohen perature frying IARC Monogr Eval Carcinog Risks. worked with Jonathan Samet chair of the Hum 95 1 430 PMID 20701241. Advisory Group meeting in 2004 and IARC to IARC 2010a Some non heterocyclic polycyclic. manage this update and ensure publication before aromatic hydrocarbons and some related exposures. IARC Monogr Eval Carcinog Risks Hum 92 1 853, the IARC Monographs meeting on ambient air PMID 21141735. pollution in October 2013 The book that resulted IARC 2013a Bitumens and bitumen emissions and. now includes the following chapters some N and S heterocyclic polycyclic aromatic hydro. carbons IARC Monogr Eval Carcinog Risks Hum 103,A working group report written by Jonathan 1 342. Samet on behalf of the Advisory Group so as IARC 2013b Diesel and gasoline engine exhausts and. some nitroarenes IARC Monogr Eval Carcinog Risks, to capture the original recommendations of Hum 105 in press.
the Advisory Group this chapter has not been Lim SS Vos T Flaxman AD et al 2012 A comparative. Air pollution and cancer IARC Secretariat Robert A Baan Paolo Boffetta Paul Brennan Vincent James Cogliano Head of Programme Fatiha El Ghissassi Yann Grosse B atrice Secretan Kurt Straif Andreas Ullrich WHO Geneva Other contributors 2 Heather Adair Rohani Department of Public Health and Environment World Health Organization Geneva

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